This module enables exploration of cohort context based on iBKH.
Given characteristics of a cohort (INPUT), the module will return cohort context in iBKH, i.e., cohort context entities (CCE) such as genes, pathways, drugs, diseases, symptoms, etc. which are potentially associated with the query cohort.
Usage:
- By specifying the Entity Type and Entity Name, the user can add multiple Cohort Entry Entities (CEE) in the left sidebar, describing profiles of the input cohort. A weight w can be specified to each CEE, indicating contribution of the CEE in the query cohort. Value of w is ranging between -1 and 1, where a value close to 1 indicates a positive contribution of the CEE on the cohort, and -1 vice versa. For an example, CEE “Depression” with a 0.75 weight indicates that we observed more “Depression” event in the query cohort compared to healthy controls or general population in an EHR system.
- Click Submit to run inference.
It will return lists of CCEs such as drugs, genes, symptoms, and pathways which are most likely to correlate to the query cohort. Such procedure may take minutes.